Detaillierte Hinweise zur Methadontabletten zur Schmerzbehandlung
Detaillierte Hinweise zur Methadontabletten zur Schmerzbehandlung
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Monoamine Oxidase (MAO) Inhibitors – Therapeutic doses of meperidine have precipitated severe reactions in patients concurrently receiving monoamine oxidase inhibitors or those who have received such agents within 14 days. Similar reactions thus far have not been reported with methadone.
The usual precautions appropriate to the use of parenteral opioids should Beryllium observed and the possibility of respiratory depression should always Beryllium kept in mind.
Teratogenic Effects. Pregnancy Category Kohlenstoff – There are no controlled studies of methadone use rein pregnant women that can be used to establish safety. However, an expert review of published data on experiences with methadone use during pregnancy by the Teratogen Information Gebilde (TERIS) concluded that maternal use of methadone during pregnancy as part of a supervised, therapeutic regimen is unlikely to Positur a substantial teratogenic risk (quantity and quality of data assessed as “limited to fair”). However, the data are insufficient to state that there is no risk (TERIS, bürde reviewed October, 2002). Pregnant women involved in methadone maintenance programs have been reported to have significantly improved prenatal care leading to significantly reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs.
A prescription for this medication isn’t refillable. You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Antibiotics, such as rifampin and rifabutin. These drugs can cause methadone to stop working. This could result hinein withdrawal symptoms. Your doctor may change your dosage of methadone as needed.
The content hinein this section is aimed at anyone involved hinein planning, implementing or making decisions about health and social responses.
Patients should Beryllium cautioned that alcohol and other CNS depressants may produce an additive CNS depression when taken with this product and should Beryllium avoided.
Didanosine and Stavudine – Experimental evidence demonstrated that methadone decreased the AUC and peak levels for didanosine and stavudine, with a more significant decrease for didanosine. Methadone disposition Methadontabletten 10 mg online was not substantially altered.
However, if the use of methadone is necessary rein such patients, a sensitivity test should Beryllium performed in which repeated small, incremental doses of methadone are administered over the course of several hours while the patient's condition and vital signs are under careful observation.
Methadone is a prescription drug. It’s an opioid, which makes it a controlled substance. This means this drug has a risk of misuse and may cause dependence.
Initial doses should be lower for patients whose tolerance is expected to Beryllium low at treatment entry. Loss of tolerance should be considered rein any patient who has not taken opioids for more than 5 days.
The respiratory depressant effects of opioids and their capacity to elevate cerebrospinal-fluid pressure may Beryllium markedly exaggerated rein the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure.
Methadone should be administered with particular caution to patients already at risk for development of prolonged QT interval (e.g., cardiac hypertrophy, concomitant diuretic use, hypokalemia, hypomagnesemia). Careful monitoring is recommended when using methadone rein patients with a history of cardiac conduction abnormalities, those taking medications affecting cardiac conduction, and hinein other cases where history or physical exam suggest an increased risk of dysrhythmia. QT prolongation has also been reported in patients with no prior cardiac history who have received high doses of methadone.